>HUMAN
----------SILKIHAREIFDSRGNPTVEVDLFTSKGLFR-AAVPSGASTGIYEALELRDNDKTRYMGK
GVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIE-MDGTEN-----KSKFGANAILGVSLAVCKAGAV
EKGVPLYRHIADLAGN-SE--VILPVPAFNVINGGSHAGN-KLAMQEFMILPVGAANFREAMRIGAEVYH
NLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGY--TDKVVIGMDVAASEFFR-S---
--GKYDLDFKSPD-DPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAG--IQVVGDD
LTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLC
TGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK-----

>RAT
----------SILKIHAREIFDSRGNPTVEVDLYTAKGLFR-AAVPSGASTGIYEALELRDNDKTRFMGK
GVSKAVEHINKTIAPALVSKKLNVVEQEKIDQLMIE-MDGTEN-----KSKFGANAILGVSLAVCKAGAV
GKGVPLYRHIADLAGN-PE--VTLPVPAFNVINGGSHAGN-KLAMQEFMILPVGASSFREAMRIGAEVYH
NLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKSAIAKAGY--TDQVVIGMDVAASEFYR-A---
--GKYDLDFKSPD-DASRYITPDQLADLYKSFIKDYPVVSIEDPFDQDDWDAWQKFTATAG--IQVVGDD
LTVTNPKRIAKAAGEKSCNCLLLKVNQIGSVTESLQACKLAQSNGWGVMVSHRSEETEDTFIADLVVGLC
TGQIKTGAPCRSERLAKYNQILRIEEELGSKAKFAGRSFRNPLAK-----

>xenopus
----------SIKNIRAREIFDSRGNPTVEVDLYTCKGLFR-AAVPSGASTGIYEALELRDNDKTRYLGK
GVGRAVKYVNEFLGPALCTQNLNVVEQEKIDKLMIE-MDGTEN-----KSKFGANALLGVSLAVCKAGAA
EKGVPLYRHIADLAGN-PE--VILPVPAFNVINGGSHAGN-KLAMQEFMILPVGADSFKEAMRIGAEVYH
NLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKTAINKAGY--PDKIVIGMDVAASEFYR-D---
--GKYDLDFKSPD-DPSRYISPDKLAELYMSFVKNYPVVSIEDPFDQDHWEAWTKFTAASG--IQVVGDD
LTVTNPKRIAKAVEEKACNCLLLKVNQIGTVTESLEACKLAQSNGWGVMVSHRSGETEDTFIADLVVGLC
TGQIKTGAPCRSERLAKYNQLLRIEEELGSKARFAGKNFRKPVFN-----

>lobster
----------SITKVFARTIFDSRGNPTVEVDLYTSKGLFR-AAVPSGASTGVHEALEMRDGDKSKYHGK
SVFNAVKNVNDVIVPEIIKSGLKVTQQKECDEFMCK-LDGTEN-----KSSLGANAILGVSLAICKAGAA
ELGIPLYRHIANLANY-DE--VILPVPAFNVINGGSHAGN-KLAMQEFMILPTGATSFTEAMRMGTEVYH
HLKAVIKARFGLDATAVGDEGGFAPNILNNKDALDLIQEAIKKAGY--TGKIEIGMDVAASEFYKQN---
--NIYDLDFKTANNDGSQKISGDQLRDMYMEFCKDFPIVSIEDPFDQDDWETWSKMTSGTT--IQIVGDD
LTVTNPKRITTAVEKKACKCLLLKVNQIGSVTESIDAHLLAKKNGWGTMVSHRSGETEDCFIADLVVGLC
TGQIKTGAPCRSERLAKYNQILRIEEELGSGAKFAGKNFRAPS-------

>squid
---------MVIKKVHSRQIFDSRGNPTVEVDLWTDKGMFR-AAVPSGASTGIYEALEMRDKDAKNYHGK
TLFNAVGNVNKIIAPALVDKKMDEKDQTAVDNFLLA-LDGTEN-----KNKLGANAILGVSLAVCKAGAA
AKGVPLYRHIADLAGN-KE--VILPVPAFNVINGGSHAGN-KLAMQEFMILPTGAKNFTEAMKMGTEVYH
HLKSVIKKKYGQDACNVGDEGGFAPNILDNKEGLELLKTAIANAGY--TAEIEIGMDVAASEFCKE----
--KKYDLDFKNPDSNPNDWLTSDQLADVYKDFVKNYPVVSIEDPFDQDDWEAYTKMTKDM--DIQIVGDD
LLVTNPKRVQKGIDLKAANALLLKVNQIGSVTESIQACKMSQDAGWGVMVSHRSGETEDTFIADLVVGLC
TGQIKTGAPCRSERLAKYNQILRIEEELGDKAVFAGKKFRNPLK------

>mescr
--------MVTIKCVKARQIYDSRGNPTVEADIHLDDGTYARAAVPSGASTGVYEALELRD-GGKDYMGK
GVYKAVKNVNEIIGPALVGK--DPTQQTAIDNFMVQQLDGTVNEWGWCKQKLGANAILAVSLAVCKAGAQ
VKKIPLYQHIAEIAGN-KN--MVLPVPAFNVINGGSHAGN-KLAMQEFMILPTGASSFKEAMKMGSEVYH
NLKSVIKKKYGQDATNVGDEGGFAPNIQENKEGLELLKTAIEKAGY--TGKVVIGMDVAASEFYKED---
--KSYDLNFKEENNDGSQRISGEALKDLYKSFVAEYPIVSIEDPFDQDDWEHYAKMTAECGEKVQIVGDD
LLVTNPKRVKKAIDENPCNALLLKVNQIGSVTESIEAVKMSKKAGWGVMASHRSGETEDTFIADLSVGLS
TGQIKTGAPCRSERLAKYNQLLRIEEELGDKAVYAGANFRRPVEPY----

>yeast
----------AVSKVYARSVYDSRGNPTVEVELTTEKGVFR-SIVPSGASTGVHEALEMRDGDKSKWMGK
GVLHAVKNVNDVIAPAFVKANIDVSDQKAVDDFLIS-LDGTAN-----KSKLGANAILGVSLAASRAAAA
EKNVPLYKHLADLSKS-KTSPYVLPVPFLNVLNGGSHAGG-ALALQEFMIAPTGAKTFAEALRIGSEVYH
NLKSLTKKRYGASAGNVGDEGGVAPNIQTAEEALDLIVDAIKAAGH--DGKVKIGLDCASSEFFK-D---
--GKYDLDFKNPNSDKSKWLTGPQLADLYHSLMKRYPIVSIEDPFAEDDWEAWSHFFKTAG--IQIVADD
LTVTNPKRIATAIEKKAADALLLKVNQIGTLSESIKAAQDSFAAGWGVMVSHRSGETEDTFIADLVVGLR
TGQIKTGAPARSERLAKLNQLLRIEEELGDNAVFAGENFHHGDKL-----

>pyhro_bac
-----MENPYEITAIVAREILDSRGNPTVEVDVHTP-IAMGRAAVPSGASTGTHEAVELRD-GGKRYHGK
GVRRAVENVNKIIAPELIGM--DVRWQREIDKLLIE-LDGTEN-----KSNLGANAILAVSLAVAKAAAN
SLELPLYQYLGGVNA------YVLPVPLSNVINGGVHAGN-ELDFQEFMIMPIGASSFREAIRWVSETYH
VLKRVIMGKYGKNAVNVGDEGGFAPPMKEVTEPLDALIKAIEEAGYKPGDEIALAIDAASSEFFK-D---
--GKYIVGGKE--------YTREELLDLYKELVSTYPIVSIEDPFHEEDWEGFVMITNELGKKIQIVGDD
LFVTNPRRLKKGIELGAANALLLKVNQIGTLTEAMDAAYTAFRAGYSVIVSHRSGETEDTTIADLAVALN
AGQIKTGAPARSDRNAKYNQLIRIEEELEGIAVYAGKNFRKVFF------

>meth
-MLYNMDERFEIKDIVAREVIDSRGNPTVEVEVITKGNGYGSAIVPSGASTGTHEALELRD-KEKRFGGK
GVLMAVENVNSIIRPEILGY--DARMQREIDTIMIE-LDGTPN-----KSRLGANAILAVSLAVAKAAAA
TAKIPLYKYLGGFNS------YVMPVPMMNVINGGKHAGN-DLDLQEFMIMPVGATSISEAVRMGSEVYH
VLKNVILEKYGKNAVNVGDEGGFAPPLKTSREALDLLTESVKKAGY--EDEVVFALDAAASEFYK-D---
--GYYYVEGKK--------LTREELLDYYKALVDEYPIVSIEDPFHEEDFEGFAMITKEL--DIQIVGDD
LFVTNVERLRKGIEMKAANALLLKVNQIGTLSEAVDAAQLAFRNGYGVVVSHRSGETEDTTIADLSVALN
SGQIKTGAPARGERTAKYNQLIRIEQELG-LSKYAGRNFRCPF-------

>myco
MGSSNLNINSKITDIFAYQVFDSRGVPTVACVVKLASGHVGEAMVPSGASTGEKEAIELRDNDPKNYFGK
GVNEAVDNVNKVIAPKLIGL--NAFDQLTVDQAMIK-LDNTPN-----KAKLGANAILSVSLAVSKAAAK
AQNSSLFQYISNKLIGLNTTNFVLPVPMLNVINGGAHADN-YIDFQEFMIMPLGAKKMHEALKMASETFH
ALQNLLKKRG--LNTNKGDEGGFAPNLKLAEDALDIMVEAIKLAGYKPWDDIAIAIDVAASEFYDEDKKL
YVFKKGIKANILN-AKDWSLTSKEMIAYLEKLTKKYPIISIEDGLSENDWEGMNQLTKTIGSHIQIVGDD
TYCTNAELAKKGVAQNTTNSILIKLNQIGSISETIQTIEVAKKANWSQVISHRSGETEDTTIADLAVAAQ
TGQIKTGSMSRSERIAKYNRLLYIEIELGDKGKYLGWNTFTNIKPKNFNI

>helicobac
--------MLTIKDIHALEVMDSRGNPTIQASVVLSDNTKASAIVPSGASTGKREALELRDNDKTRFLGK
GVLRACENVNSVIKHHLIGL--EAINQAFVDERLRA-LDGTPN-----YANLGANAVLGVSMALARASAK
ALNLPLYRYLG------GANALTLPVPMLNIINGGTHANN-SIDFQEYMIMPLGFESFKEALRASAEVYH
TLKKLLDGKN--QLTSVGDEGGFAPNFSNNVEPLEVISQAIEKAGYKLGEEIALALDVASSELVDEN---
--FNYHLKG------ENKILDSHELVAYYKELVAKYPIVSIEDGLSEDDWEGWAFLSKELGRQIQLVGDD
LFVTNASLLQKGIEKNIANAVLIKPNQIGTISETLETIRLAKHHAYQCVMSHRSGESEDSFIADFAVALN
TGEIKTGSTARSERIAKYNRLLEIEHELKG-GIYIGKELFKHG-------

>thermacq_bac
--------MSRIKRVHGREVLDSRGNPTVEVEVELESGALGRAIVPSGASTGEREALELRDGDPKRYLGK
GVLKAVDNVNGVIAKALVGL--EPYNQREIDQILIE-LDGTEN-----KSKLGANAILGTSMAVARAAAN
ELGIPLYEYLG------GKFGYRLPVPLMNVINGGAHADN-NLDIQEFMIVPVCGGAFREALRAGVETFH
HLKKILKEKG--YSTNVGDEGGFAPNLNSSEEALDILMQAIEKAGYKPGEDILLALDVASSEFYENG---
---VYKFEG--------KERSAEEMIEFYEKLIQKYPIISIEDPMSENDWEGWKEITKRLGDKVQLVGDD
LFTTNPKILRKGIEEGVANAILVKLNQIGTVSETLDTVMLAKERNYSAIISHRSGETEDTFISHLAVATN
AGQIKTGSASRTDRIAKYNELLRIEERLGNGAVFWGREEFYRFTS-----

>Ecoli_bac
---------SKIVKIIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGK
GVTKAVAAVNGPIAQALIGK--DAKDQAGIDKIMID-LDGTEN-----KSKFGANAILAVSLANAKAAAA
AKGMPLYEHIAELNG--TPGKYSMPVPMMNIINGGEHADN-NVDIQEFMIQPVGAKTVKEAIRMGSEVFH
HLAKVLKAKG--MNTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDG---
---KYVLAGE-----GNKAFTSEEFTHFLEELTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDD
LFVTNTKILKEGIEKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTA
AGQIKTGSMSRSDRVAKYNQLIRIEEALGEKAPYNGRKEIKGQA------

>meth2_bac
-------MESIIEDVRVRKILDSRGNPTVEVDVITWNG-FGRAAAPSGASTGSREVAAFPS--------G
GVDEIITEVEDIISSELIGM--DAVDLQDIDLVLKE-IDGTEN-----LSSLGGNTVVAVSMATAKAAAS
SYNMPLYRFLGGNLA--TS----IPYPLGNMINGGAHAGKNAPDIQEFLVVPVGAEDITEAVFANAAVHK
RIRELIQKKDPSFAGGKGDEGGWVPSLSNG-DALEIQATACEEVTDELGVEVRPSLDLAASEFWDPEI--
--EKYVYRQ------ENVQKDTGEQIEFVKEIIETYDMYYVEDPLHEGDLEGFAELTSLVGDRCMICGDD
IFVTNREILREGIEMGAANAIIIKPNQIGTLTDTYLTVKLALENRYTPVVSHRSGETTDDTIAHLAVAFG
APLIKTGAIG-GERIAKLNELIRIQEEIPY-SRMADLPF-----------

>halo
--------MTLITDIRLRRVLDSRGNATVEADVLTESGGFGRGKAPSGASTGEYEAIELPA--------N
--EAIAKAREEALPRLIGEV--HAGNQRDVDTALHA-ADGTDD-----FSGIGANSAVAISMAAAKAGAD
VLGAPLYQHLGGTFR--GNE---YPTPLGNIIGG-EHAAD-ATNIQEFLAAPVGAPSVEEAVFANAAVHQ
EVHDILADRD--LPAGKGDEGAWAPSVSDD-EAFEIMDEAVETVADDFGFAISFGLDVARAELYDDEA--
--DGYVY--------DDGVKSTEEQIEYIAGKVEEYDLVYVEDPLDENDYEAFADLTAQVGDQTLVCGDD
LFVTNVERLQAGINADAGNSILIKPNQIGTLTDAVDAIELATASGYESVVSHRSGETEDTTIAHLAVATD
APFIKTGAVG-GERTAKLNELIRIEDNAV---------------------